Peripheral Receptor Targets for Analgesia: Novel Approaches by Brian E. Cairns

By Brian E. Cairns

Content material:
Chapter 1 function of Peripheral Mechanisms in Craniofacial soreness stipulations (pages 1–20): Barry J. Sessle
Chapter 2 function of Peripheral Mechanisms in Spinal discomfort stipulations (pages 21–40): Brian E. Cairns and Pradit Prateepavanich
Chapter three Voltage?Gated Sodium Channels in Peripheral Nociceptive Neurons as ambitions for the therapy of ache (pages 41–91): Theodore R. Cummins
Chapter four Potassium Channels (pages 93–110): Daisuke Nishizawa, Toru Kobayashi and Kazutaka Ikeda
Chapter five Voltage?Gated Calcium Channels as goals for the therapy of continual discomfort (pages 111–136): Joseph G. McGivern
Chapter 6 Adenosine Receptors (pages 137–152): Jana Sawynok
Chapter 7 Acid?Sensing Ion Channels and ache (pages 153–174): Roxanne Y. Walder, Christopher J. Benson and Kathleen A. Sluka
Chapter eight Vanilloid (TRPV1) and different temporary Receptor strength Channels (pages 175–213): Marcello Trevisani and Arpad Szallasi
Chapter nine Glutamate Receptors (pages 215–241): Brian E. Cairns
Chapter 10 Serotonin Receptors (pages 243–274): Malin Ernberg
Chapter eleven Adrenergic Receptors (pages 275–296): Antti Pertovaara
Chapter 12 Cholinergic Receptors and Botulinum Toxin (pages 297–324): Parisa Gazerani
Chapter thirteen Cannabinoids and ache regulate within the outer edge (pages 325–345): Jason J. McDougall
Chapter 14 Opioid Receptors (pages 347–372): Claudia Herrera Tambeli, Luana Fischer and Carlos Amilcar Parada
Chapter 15 Calcitonin Gene?Related Peptide and Substance P (pages 373–396): Ranjinidevi Ambalavanar and Dean Dessem
Chapter sixteen function of Somatostatin and Somatostatin Receptors in soreness (pages 397–417): Ujendra Kumar
Chapter 17 Cytokines (Tumor Necrosis issue, Interleukins) and Prostaglandins (pages 419–454): in step with Alstergren
Chapter 18 Neurotrophic components and ache (pages 455–472): Peter Svensson
Chapter 19 Topical and Systemic Drug supply platforms for distinct remedy (pages 473–514): Urs O. Hafeli and Amit Kale
Chapter 20 Gene remedy for discomfort (pages 515–528): Marina Mata and David J. Fink
Chapter 21 Topical Analgesics (pages 529–535): Akhlaq Waheed Hakim and Brian E. Cairns

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Additional resources for Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management

Example text

Interestingly, it has been found that ∼5–15% of afferent fibers that innervate the uterus appear to have collateral branches that innervate the colon [27]. If these fibers convey noxious information, this finding suggests that excitation of afferent endings in one organ could potentially alter afferent sensitivity in the other organ. 2). 2. Both peripheral and central mechanisms can lead to the development of neuropathic pain conditions. A key change in this process is the development of central sensitization, which is mediated through an increase in glutamatergic synaptic activity.

Toothaches, headaches, TMD), and the role that peripheral mechanisms may play in each of these and other craniofacial pain conditions is outlined. 18 ROLE OF PERIPHERAL MECHANISMS IN CRANIOFACIAL PAIN CONDITIONS ACKNOWLEDGMENT Cited studies by the author have been supported by the National Institutes of Health grants DE04786 and 15420 and CIHR grant MOP 4918. REFERENCES 1. , Larach-Robinson, D. (1997). Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 124:115–121.

P. ). Orofacial Pain, 2nd ed. Chicago, IL: Quintessence, pp. 179–185. 29. , Goldman, J. (2001). Substance P immunoreactive sensory axons as a subset of the total axonal population in the maxillary sinus of the rabbit: a characterization of normal and infected mucosa. Am J Rhinol 15:61–67. 30. J. (2004). Neuropathic pain in the orofacial region: clinical and research challenges. J Orofac Pain 18:281–286. 31. B. (2008). Management of neuropathic pain. P. ). Orofacial Pain, 2nd ed. Chicago, IL: Quintessence, pp.

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