Neurodegeneration and Neuroprotection in Parkinson's Disease by C. W. Olanow, Peter Jenner, Moussa Youdim

By C. W. Olanow, Peter Jenner, Moussa Youdim

Neuroscience views presents multidisciplinary studies of themes in a single of the main divers and speedily advancing fields within the lifestyles sciences. no matter if you're a new recruit to neuroscience, or a longtime specialist, glance to this sequence for 'one-stop' resources of the historic, physiological, pharmacological, biochemical, molecular organic, and healing features of selected study parts.

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First, the post-mortem stability of vitamin C and vitamin E, and the effect of post-mortem delay and freezing have not been studied. Second, the rate of conversion between the oxidized and reduced forms of these vitamins has not been measured and may be considerably increased in the presence of excess free radical formation. Changes in SOD activity in PD have been measured in two recent studies. , 1989). No changes were detected in the constituent Cu/Zn-dependent cytosolic form of the enzyme. , 1988).

Biol. Chem. 265, 16330-16336. 21 This Page Intentionally Left Blank CHAPTER 2 PATHOLOGICAL EVIDENCE FOR OXIDATIVE STRESS IN PARKINSON'S DISEASE AND RELATED DEGENERATIVE DISORDERS P. W. 12 Introduction Alterations in iron in PD Alterations in mitochondrial function Alterations occurring in protective enzyme systems Alterations in glutathione content Oxidative damage in PD Role of levodopa in alterations in indices of oxidative stress Oxidative stress and incidental Lewy body disease Other related studies Which comes first?

H. R. (1978) Proc. Nutr. Soc. 37, 173-179. M. A. (1985) Neurochem. Res. 10, 397-410. , Fielden, R et al. (1992)AgeAgeing 10, 125-132. Zhang, J. A. (1991)J. Appl. Physiol. 71, 1057-1061. , Ernster, L. A. (1990)J. Biol. Chem. 265, 16330-16336. 21 This Page Intentionally Left Blank CHAPTER 2 PATHOLOGICAL EVIDENCE FOR OXIDATIVE STRESS IN PARKINSON'S DISEASE AND RELATED DEGENERATIVE DISORDERS P. W. 12 Introduction Alterations in iron in PD Alterations in mitochondrial function Alterations occurring in protective enzyme systems Alterations in glutathione content Oxidative damage in PD Role of levodopa in alterations in indices of oxidative stress Oxidative stress and incidental Lewy body disease Other related studies Which comes first?

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