Metal Ion Controlled Reactivity by Rudi van Eldik and Colin D. Hubbard (Eds.)

By Rudi van Eldik and Colin D. Hubbard (Eds.)

The Advances in Inorganic Chemistry sequence current well timed and informative summaries of the present growth in numerous topic components inside of inorganic chemistry, starting from bio-inorganic to reliable nation experiences. This acclaimed serial positive aspects experiences written by means of specialists within the box and serves as an crucial connection with complex researchers. each one quantity comprises an index, and every bankruptcy is totally referenced. * beneficial properties finished stories at the newest advancements * contains contributions from prime specialists within the box * Serves as an crucial connection with complex researchers. learn more... summary: provides informative summaries of development in a number of topic components inside inorganic chemistry, starting from bio-inorganic to stable country stories. This name complicated researchers. every one quantity includes an index, and every bankruptcy is totally referenced. This identify gains entire studies on advancements within the box. learn more...

Show description

Read Online or Download Metal Ion Controlled Reactivity PDF

Best chemistry books

Recent Developments in Carbocation and Onium Ion Chemistry (Acs Symposium Series 965)

The quantity is a set of twenty-two chapters written through best specialists and energetic researchers within the box targeting a variety of elements of carbocation and onium ion chemistry. those contain good ion NMR stories, solvolytic and kinetic reviews, computational paintings, and synthetic/preparative points.

The Adrenocortical Hormones: Their Origin · Chemistry Physiology and Pharmacology

2 Vol. three: Hormones, Psychology and behaviour (1952). quite a number pursuits was once coated in appreciate to the effect of glucocorticoids on behavioral responses, in addition to to the glucocorticoid prestige in a variety of behavioral states and issues. Vol. four: Anterior Pituitary Secretion and Hormonal effect in Water Metab­ olism (1952).

Additional resources for Metal Ion Controlled Reactivity

Sample text

A. BRUIJNINCX AND PETER J. SADLER and Nd to ruthenium. Competitive binding experiments of [Ru(Z6-bip)Cl(en)]þ with an oligonucleotide and either L-histidine or cytochrome c showed almost selective binding to the oligonucleotide and neither the amino acid nor the protein can compete effectively with the guanine site in the oligonucleotide (91). Reaction with the sulfur-containing amino acids L-cysteine and L-methionine appear to play a major role in the biological chemistry of both Pt(II), Pt(IV), and Ru(III) anticancer agents, making it important to study these interactions with Ru(II)– arenes as well.

Generally, but not always, complexes that readily hydrolyze are cytotoxic. An interesting exception to this rule is [Ru(en) (Z6-hmb)(SPh)]þ (18), which hydrolyzes extremely slowly yet shows significant activity. Closer inspection of the reactivity of this and related compounds suggests an ‘‘activation-by-ligand-oxidation’’ mechanism and led to our studies on ruthenium–sulfenate and – sulfinate complexes that will be further discussed below. The chelating ligand also influences the hydrolysis rate.

The changes involve rotation around the arene–Ru pbonds, twisting around the Ph–Ph bond (bip), and ring bending (dha, tha). The arene ligands thus possess the flexibility to optimize the geometry for simultaneous covalent binding and arene–base stacking. This may reduce the steric demands of the Ru drug and enhance the DNA affinity. 8 Å, N–H Á Á Á O angle 1631). This strong hydrogen bonding interaction partly accounts for the high preference for binding of {Ru(Z6-arene)(en)}þ to G versus A. Indeed, subsequent studies on the thermodynamics and kinetics of binding of ([Ru(Z6-arene)Cl(en)]þ) (arene ¼ bip, dha, tha) to mononucleotides and mononucleosides (G, A, C, and T) confirmed the importance of these specific interactions.

Download PDF sample

Rated 4.59 of 5 – based on 22 votes