By Steve Levison
This article presents a accomplished precis of analysis and findings that experience result in the present figuring out of the subventricular zones. It presents an outline of the jobs of subventricular zones in general improvement and in affliction and a beginning from which present and destiny experiences should be evaluated.
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Extra info for Mammalian Subventricular Zones: Their Roles in Brain Development, Cell Replacement, and Disease
J. E. (1993b). The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated. Development 119: 611–623. 1. W. E. (1993). Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain. Neuron 10: 201–12. W. E. (1997). Multipotential and lineage restricted precursors coexist in the mammalian perinatal subventricular zone. J. Neurosci. Res. 48: 83–94. M. E. (1999). Cycling cells in the adult rat neocortex preferentially generate oligodendroglia.
See comments]. Science 278: 474–476. B. L. (1961). Autoadiographic study of cell migration during histogenesis of cerebral cortex in the mouse. Nature 192: 766–768. , Volpe, B. H. (2001). Phenotypic differentiation during migration of dopaminergic progenitor cells to the olfactory bulb. J. Neurosci. 21: 8505–8513. A. and Altman, J. (1991). Neocortical Development. New York, NY Raven Press. , and Gallo, V. (2003). Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons.
The majority of the p75þ cells are identified also by EGFR immunoreactivity. , 2004), thus suggesting that p75 is mainly expressed in the fast-proliferating cell population. , 2005), while the full-length and truncated form of TrkB receptors are both present. , 1995). Therefore, it is not surprising that BDNF is the primary neurotrophin-affecting neurogenesis in the adult SVZ (Kirschenbaum and Goldman, 1995). , 1998). , 2001), it is thought that the proliferative effect of BDNF is mediated by signaling through the low affinity p75 receptor in the fast proliferating cell population.