Macrolide Antibiotics: Chemistry, Biology, and Practice, 2nd by Satoshi Omura

By Satoshi Omura

Macrolide Antibiotics: Chemistry, Biochemistry, and perform, moment version explores the invention of recent macrolide antibiotics, their functionality, and their medical use in ailments equivalent to melanoma, AIDS, cystic fibrosis and pneumonia. This booklet discusses the construction of artificial macrolides and the mechanisms of antibiotic job. The makes use of for antimicrobial macrolides in scientific perform also are coated. This ebook is designed to attract either the fundamental and utilized examine groups drawn to microbiology, bacteriology, and antibiotic/antifungal examine and treament.

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It showed potent and selective inhibitory activity toward mammalian mitochondrial respiratory chain complex I. Salvifoliolide (122) is a 9-membered ring macrolide produced by Trichogonia sp. [151]. Its skeleton may be derived from sesquiterpene. Lasiodiplodin (123) is a 12-membered ring macrolide isolated from Euphorbia splendens [152]. It showed a potent antileukemic activity. Some simple monolactones produced by plants have good flavor such as musky odor, and some are contained in essential oils and used as perfume [ 153].

Kim, Y. , and Seto, H. (1991). Isolation and structural elucidation of sekothrixide, a new macrolide effective to overcome drug-resistance of cancer cell. J. Antibiot. 44, 1280-1282. 24. , and Imoto, M. (2001). Migrastatin, a novel 14-membered ring macrolide, inhibits anchorage-independent growth of human small cell lung carcinoma Ms-1 cells. J. Antibiot. 54, 1104-1107. 25. , and Ito, S. (1953). Leucomycin, a new antibiotic. J. Antibiot. Ser. A 6, 87-89. 26. Burg, R. , Miller, B. , Baker, E. , Currie, S.

96. Bollag, D. , McQueney, P. , and Woods, C. M. (1995). Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. 55, 2325-2333. 97. , and Hoefle, G. (1993). Antibiotics from gliding bacteria. LIV. Isolation and structure elucidation of soraphen AI~, a novel antifungal macrolide from Sorangium cellulosum. Liebigs Ann. Chem. 1017-1021. 98. Vahlensieck, H. , and Hinnen, A. (1994). Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A.

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