Hemochromatosis - A Bibliography and Dictionary for by Philip M. Parker

By Philip M. Parker

In March 2001, the nationwide Institutes of well-being issued the next caution: ''The variety of websites supplying health-related assets grows each day. Many websites supply worthy info, whereas others could have details that's unreliable or misleading.'' moreover, as a result of quick elevate in Internet-based info, many hours will be wasted looking, opting for, and printing. in view that purely the smallest fraction of data facing hemochromatosis is listed in se's, corresponding to www.google.com or others, a non-systematic method of web examine may be not just time eating, but additionally incomplete. This e-book was once created for doctors, scholars, and participants of most people who are looking to behavior scientific examine utilizing the main complex instruments to be had and spending the smallest amount of time doing so.

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It is hoped that this work will provide clues leading to new treatment strategies for disorders of iron overload such as hemochromatosis and disorders of iron deficiency such as anemia of chronic disease. ; Professor of Medicine; Medicine; Medical College of Wisconsin 8701 Watertown Plank Rd Milwaukee, Wi 532260509 Timing: Fiscal Year 2005; Project Start 01-APR-2005; Project End 31-MAR-2009 Summary: (provided by applicant): The mortality from lymphoma is high; thus, there is a great need to not only develop new therapeutic agents for this disease but to also further develop agents that have already shown promise in prior investigations.

The focus of this application is to test the hypothesis that neogenin functions as a receptor for RGMc. The following Specific Aims are proposed to test this hypothesis: 1. to define the nature of the interaction between RGMc and neogenin, 2; to determine whether neogenin mediates the biological actions of RGMc. Studies • 25 Project Title: CHEMICAL GENETICS OF IRON TRANSPORT Principal Investigator & Institution: Wessling-Resnick, Marianne; Professor; Nutrition; Harvard University (Sch of Public Hlth) Public Health Campus Boston, Ma 02115 Timing: Fiscal Year 2005; Project Start 15-JUL-2004; Project End 30-JUN-2008 Summary: (provided by applicant): Chemical genetics is an emerging field that takes advantage of combinatorial chemical and small molecule libraries to dissect complex biological processes.

These may include (1) hephaestin (2) HFE (3) transferrin receptor (4) novel genes including the postulated iron stores regulator and erythropoietic regulator (5) alternative iron transporters. In addition we expect to find gain of function mutations in the ferroportin1 gene itself. Performing a mutagenesis screen facilitates evaluation of the 32 Hemochromatosis interactions of all these factors simultaneously and may result in the identification of novel genes involved in iron homeostasis. These novel genes may become molecular targets for the treatment of iron overload conditions, such as hereditary hemochromatosis.

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