Lupus - A Medical Dictionary, Bibliography, and Annotated by Icon Health Publications

By Icon Health Publications

This can be a 3-in-1 reference publication. It supplies an entire scientific dictionary overlaying thousands of phrases and expressions in terms of lupus. It additionally offers broad lists of bibliographic citations. ultimately, it presents details to clients on tips to replace their wisdom utilizing a number of net assets. The ebook is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to familiarize yourself with study devoted to lupus. in case your time is efficacious, this publication is for you. First, you won't waste time looking out the web whereas lacking loads of appropriate info. moment, the ebook additionally saves you time indexing and defining entries. eventually, you won't waste money and time printing hundreds and hundreds of web content.

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Extra resources for Lupus - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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To definitely establish whether CSF-1 or other cytokines have an enhanced glomerular expression prior to the influx of macrophages, we will isolate and pool individual glomeruli (glom) from MRL-lpr/lpr, congenic, and normal mice at varying ages and quantitate the level of cytokine and macrophages specific marker mRNA using the competitive template polymerase chain reaction. Finally, we will cross the MRL-++ or the C3H- lpr/lpr mice with CSF-1 transgenic mice and select for hybrids with these backgrounds overexpressing macrophage growth factors.

The hypothesis to be pursued is that in SLE, impaired regulation of T cell activation results in excessive Th cell function, autoantibody formation, inflammation, and disease. CD40L is both a marker and mediator of this abnormal T cell help. The specific aims of the project are: I. To Study the Regulation of CD40L Expression in Human T Cells. We will investigate the T cell stimuli required for induction of CD40L mRNA and protein expression, the biochemical pathways that mediate induction of CD40L, the regulation of soluble CD40L production, and the effect of cytokines on expression of cell surface and soluble CD40L.

Furthermore, the studies should also provide a more complete definition of CD1c+B cells, a population of B cells that arises early in the development of the immune system, but whose function remains unknown. Finally, we anticipate that our findings will be useful in establishing new mains of treating autoimmune disease. Generate_Screen • Project Title: CD19 TYROSINE MEDIATED SIGNAL TRANSDUCTION IN VIVO Principal Investigator & Institution: Carter, Robert H. Associate Professor; Medicine; University of Alabama at Birmingham Uab Station Birmingham, AL 35294 Timing: Fiscal Year 2002; Project Start 01-JAN-1998; Project End 31-JAN-2007 Summary: (provided by applicant): B cells are involved in many autoimmune diseases.

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