Contrast Agents II: Optical, Ultrasound, X-Ray and by Kai Licha (auth.), Prof. Dr. Werner Krause (eds.)

By Kai Licha (auth.), Prof. Dr. Werner Krause (eds.)

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42 42 43 43 . 44 . 45 . 47 . 48 4 Renal Function Monitoring . . . . . . . . . . . 4 Basic Renal Anatomy and Physiologic Function . . . Renal Function Disorders and Measurements . . . Markers Excreted by Glomerular Filtration . . . . Creatinine Clearance . . . . . . . . . . Iodinated Aromatic Markers . . . . . . . . Metal Complexes . . . . . . . . . . . Organic Dyes . . . . . . . . . . . . Continuous Renal Function Monitoring with Exogenous Organ-Specific Clearance Markers .

Biotransformation of MAMC to HAMC results in emission (lmax) shift from 396 to 470 nm. Thus, metabolism of coumarin can be monitored continuously and quantified by spectroscopic techniques. Fig. 6. Biotransformation of 7-methoxy-4-(aminomethyl) coumarin (MAMC,emission 396 nm) to 7-hydroxy-4-(aminomethyl) coumarin (HAMC, emission 470 nm) by cytochrome P450 enzyme CYP2D6 Newer and potentially better hepatic function index continues to captivate researchers. A recent report indicates that hippurate ratio is a good measure of functional hepatocyte capacity [13].

44 . 45 . 47 . 48 4 Renal Function Monitoring . . . . . . . . . . . 4 Basic Renal Anatomy and Physiologic Function . . . Renal Function Disorders and Measurements . . . Markers Excreted by Glomerular Filtration . . . . Creatinine Clearance . . . . . . . . . . Iodinated Aromatic Markers . . . . . . . . Metal Complexes . . . . . . . . . . . Organic Dyes . . . . . . . . . . . . Continuous Renal Function Monitoring with Exogenous Organ-Specific Clearance Markers .

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