Chemistry of Taste. Mechanisms, Behaviors, and Mimics by Peter Given and Dulce Paredes (Eds.)

By Peter Given and Dulce Paredes (Eds.)

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It would be useful to provide a molecular explanation for the occurrence of synergy in humans. The challenge is to explore this hypothesis without biochemical evidence and to test molecular models using psychophysical data. 0 Component A ch003 Figure 1. Linear and non-linear isoboles Models Based on the Law of Mass Action When a substance (A), an agonist, binds a receptor (R) to produce an agonist-receptor complex (AR), it is assumed that this binding process is reversible, A + R <-» A R . From the Law of Mass Action [AR]/[RJ = K,[A]/{l+K [A]}, a (1) where [A] represents the concentration of A , K is the association constant for A binding to R, and [RJ is the total receptor concentration.

ACS Symposium Series; American Chemical Society: Washington, DC, 2002. 51 ch004 52. Kitagawa M . ; Kusakabe, Y . ; Miura, H . ; Ninomiya, Y . ; Hino, Α. Biochemistry Biophysics Research Communication 2001, 283: 236-242. 53. ; Shanker, Y . G . ; Huan, L . ; Rong, M . ; Liu, Z . ; Weinstein, H . F. Nature Genetics 2001, 28, 5863. 54. ; Matsunami, H . ; Buck, L . B . Nature Neuroscience 2001 4, 492-498. 55. ; Hoon, M . A . ; Zhang, Y . S. Cell 2001, 106: 381-390. 56. L J. , 2001, 77, 896-903. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2002.

All twin pairs) like a food very much, then ceiling effects may reduce individual variation, which precludes genetic analysis. Food diaries may provide more accurate estimates of the foods subjects eat, but because food intake is usually only measured for a brief period (3-7 days), it may not be representative of the subjects' food selection habits. Diary data may also be inaccurate due to reporting biases of subjects. With these limitations in mind, we review studies of preferences for individual food items generally regarded as sweet followed by studies of sweet carbohydrate selection patterns.

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