Ceramide Signaling by Anthony H. Futerman

By Anthony H. Futerman

The amount assembles present details at the function of ceramide as a signalling molecule in sixteen chapters written through best staff during this sector. particular cognizance is given to mechanisms of research of ceramide and its biophysical houses, on enzymes of ceramide metabolism and down-stream objectives of ceramide, at the cross-talk of ceramide signalling with different signalling pathways, and at the function of ceramide in neuronal signalling. eventually, the booklet closes with a piece at the healing implications of ceramide motion, within the parts of cannabinoid motion, chemotherapy, and atherosclerosis, and illustrates the capability clinical value of delineating the jobs of ceramide in mobilephone signalling. this can be the 1st quantity particularly dedicated to ceramide signalling, and may act as a useful source for uncomplicated and clinical researchers and graduate scholars wishing to get a state-of-the-art evaluation of this swiftly relocating box.

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Clin Cancer Res 1996; 2:1-6. 19. Weiss B, Stoffel W. Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur J Biochem 1997; 249:237-247. 20. Huwiler A, Kolter T, Pfeilschifter J et al. Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim Biophys Acta 2000; 1485:63-99. 21. Holopainen JM, Subramaniam M, Kinnunen PKJ. Sphingomyelinase induced lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane.

1,54 The formation of ceramide in membranes could facilitate the bilayer association of specific peripheral membrane proteins. 61 However, peripheral proteins lacking selective interactions with ceramide could also be influenced by this lipid. As outlined above, the formation of ceramide in the membrane changes its bulk physical properties by increasing surface hydrophobicity as well as the propensity of the membrane to form inverted nonlamellar phases, changing the bilayer lateral pressure profile.

In: Lasic DD, Barenholz Y, eds. Nonmedical Applications of Liposomes. Boca Raton: CRC Press, 1996a:153-171. 5. Kinnunen PKJ. On the molecular-level mechanism of peripheral protein-membrane interactions induced by lipids forming inverted nonlamellar phases. Chem Phys Lipids 1996b; 81:151-166. 6. Lehtonen JYA, Kinnunen PKJ. Phospholipase A2 as a mechanosensor. Biophys J 1995; 68:1888-1894. 7. Kinnunen PKJ, Holopainen JM. Mechanisms of initiation of membrane fusion: Role of lipids. Biosci Rep 2000; 20:465-482.

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