Asthma by Timothy John Hayes Clark

By Timothy John Hayes Clark

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5). It may be, therefore, that the irreversible airway remodelling processes that occur in COPD and in certain asthmatics lead both to progressive fall in FEV1 and to increased BHR, whilst in asthmatics with completely reversible airflow obstruction, the BHR is caused by inflammation. , 1994a), though it is likely that both theories may apply since BHR is a manifestation of so many properties of the airway. , 1991). This variation may, over relatively short periods of time, be associated with exacerbations of asthma or may occur in a diurnal pattern, with a marked reduction in PEF occurring in the morning (Fig.

1961). The host factor in bronchitis. In: Orie NGM, Sluiyer HJ, eds. Assen, Netherlands: Royal van Gorcum, 43-59. Oswald H, Phelan PD, Lanigan A, et al. (1997) Childhood asthma and lung function in mid-adult life. PediatrPulmonol, 23,14-20. Overbeek SE, Kerstjens HAM, Bogaard JM, etal. (1996) Is delayed introduction of inhaled corticosteroids harmful in patients with obstructive airways disease (asthma and COPD)? Chest, 110,34-41. Pattemore PK, Asher Ml, Harrison AC, et al. (1990) The interrelationship among bronchial hyperresponsiveness, the diagnosis of asthma and asthma symptoms.

However, Saetta et al. (1989) reported a case of fatal asthma in a patient demonstrating severe BHR but stable PEFs. The correlation between PEF variability and BHR also depends on the method by which BHR is assessed and the way in which PEF variability is calculated. A variety of measures of PEF variability have been suggested, including the amplitude of variation expressed as a percentage of the mean, or the standard deviation of the PEF over a period of time, or the lowest PEF as a percentage of the highest.

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